ALK: a tyrosine kinase target for cancer therapy
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منابع مشابه
ALK: a tyrosine kinase target for cancer therapy
The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the development of the brain and can be oncogenically altered in several malignancies, including non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphomas (ALCL). Most prevalent ALK alterations are chromosomal rearrangements resulting in fusion genes, as seen in ALCL and NSCLC. In other tumors, ALK cop...
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Anaplastic large-cell lymphoma (ALCL) is frequently associated with the 2;5 translocation and expresses the NPM-ALK fusion protein, which possesses a constitutive tyrosine kinase activity. We analyzed SHP1 tyrosine phosphatase expression and activity in 3 ALK-positive ALCL cell lines (Karpas 299, Cost, and SU-DHL1) and in lymph node biopsies (n = 40). We found an inverse correlation between the...
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The mechanism of action of the two isoforms of the PKA, defined PKAI and PKAII, respectively, has been the object of study for almost 25 years. However, only during the past decade, experimental evidences have started to confer distinct functions to PKAI and PKAII and have demonstrated that their intracellular balanced expression may play a critical role in the control of cell growth and differ...
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INTRODUCTION Inhibition of protein kinases has become a standard of modern clinical oncology. PIM1 belongs to a novel class of serine/threonine kinases with distinct molecular and biochemical features regulating various oncogenic pathways, for example hypoxia response, cell cycle progression and apoptosis resistance. PIM1 is overexpressed in human cancer diseases and has been associated with me...
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ژورنال
عنوان ژورنال: Molecular Case Studies
سال: 2017
ISSN: 2373-2865,2373-2873
DOI: 10.1101/mcs.a001115